                         SEQUENCE LISTING

<110>  IPSEN PHARMA S.A.S.
       DONG, Zheng Xin
       ZHANG, Jundong
 
<120>  Pharmaceutical Compositions of Analogues of Glucose-Dependent 
       Insulinotropic Polypeptides

<130>  201P2/PCT2

<150>  61/200,616
<151>  2008-12-02

<150>  61/188,204
<151>  2008-08-07

<160>  295   

<170>  PatentIn version 3.5

<210>  1
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  1

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  2
<211>  42
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (42)..(42)
<223>  AMIDATION

<400>  2

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  3
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  3

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  4
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  4

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  5
<211>  24
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  AMIDATION

<400>  5

Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys 
            20                  


<210>  6
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  6

Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys 
            20                  


<210>  7
<211>  25
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  AMIDATION

<400>  7

Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp 
1               5                   10                  15      


Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25  


<210>  8
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  8

Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp 
1               5                   10                  15      


Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25  


<210>  9
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)

<400>  9

Tyr Ala Pro Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  10
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (42)..(42)
<223>  AMIDATION

<400>  10

Tyr Ala Pro Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  11
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<400>  11

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  12
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MOD_RES
<222>  (42)..(42)
<223>  AMIDATION

<400>  12

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  13
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<400>  13

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  14
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  14

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  15
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  15

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  16
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  16

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Xaa Thr Gln 
        35                  40          


<210>  17
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  17

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  18
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  18

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln Asn 
        35                  40              


<210>  19
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MOD_RES
<222>  (43)..(43)
<223>  AMIDATION

<400>  19

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln Asp 
        35                  40              


<210>  20
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  20

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Xaa Thr Gln 
        35                  40          


<210>  21
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  21

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Xaa Thr Gln 
        35                  40          


<210>  22
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  22

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln Ala 
        35                  40              


<210>  23
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  23

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln Phe 
        35                  40              


<210>  24
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  24

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln Thr 
        35                  40              


<210>  25
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  25

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  26
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<400>  26

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln Trp 
        35                  40              


<210>  27
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  Xaa = 12-aminododecanoic acid (Ado)

<400>  27

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln Xaa 
        35                  40              


<210>  28
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  28

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Xaa Thr Gln 
        35                  40          


<210>  29
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (42)..(42)
<223>  modified with  N-propylsuccinimide

<400>  29

Tyr Ala Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Cys 
        35                  40          


<210>  30
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  30

Tyr Ala Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  31
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  31

Tyr Ala Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  32
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa = ornithine (Orn)

<220>
<221>  MOD_RES
<222>  (35)..(35)
<223>  modified with (N-C(O)-(CH2)12-CH3)

<400>  32

Tyr Ala Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Xaa Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  33
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa = ornithine (Orn)

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  modified with (N-C(O)-(CH2)12-CH3)

<400>  33

Tyr Ala Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Xaa Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  34
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  34

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  35
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  35

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  36
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa = ornithine (Orn)

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  modified with (N-C(O)-(CH2)14-CH3)

<400>  36

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Xaa 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  37
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa = ornithine (Orn)

<220>
<221>  MOD_RES
<222>  (33)..(33)
<223>  modified with (N-C(O)-(CH2)14-CH3)

<400>  37

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Xaa Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  38
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  Xaa = ornithine (Orn)

<220>
<221>  MOD_RES
<222>  (43)..(43)
<223>  modified with (N-C(O)-(CH2)14-CH3)

<400>  38

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln Xaa 
        35                  40              


<210>  39
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  modified with succinimide-N-(CH2)15-CH3

<400>  39

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Cys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  40
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (33)..(33)
<223>  modified with succinimide-N-(CH2)15-CH3

<400>  40

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Cys Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  41
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (43)..(43)
<223>  modified with succinimide-N-(CH2)15-CH3

<400>  41

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln Cys 
        35                  40              


<210>  42
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa =  3-(4-hydroxyphenyl)propionic acid (4Hppa)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  42

Xaa Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  43
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa =  3-(4-hydroxyphenyl)propionic acid (4Hppa)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  43

Xaa Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  44
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa =  3-(4-hydroxyphenyl)propionic acid (4Hppa)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  44

Xaa Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  45
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa =  3-(4-hydroxyphenyl)propionic acid (4Hppa)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  45

Xaa Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  46
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa =  3-(4-hydroxyphenyl)propionic acid (4Hppa)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  46

Xaa Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  47
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa =  3-(4-hydroxyphenyl)propionic acid (4Hppa)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  47

Xaa Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  48
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa =  3-(4-hydroxyphenyl)propionic acid (4Hppa)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  48

Xaa Ala Xaa Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  49
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa =  3-(4-hydroxyphenyl)propionic acid (4Hppa)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa = homoproline (hPro)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  49

Xaa Ala Xaa Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  50
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa =  3-(4-hydroxyphenyl)propionic acid (4Hppa)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa = homoproline (hPro)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  50

Xaa Xaa Xaa Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  51
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  51

His Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  52
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  brominated at positions 3 and 5

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  52

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  53
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  53

His Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  54
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  brominated at positions 3 and 5

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  54

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  55
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  chlorinated at position 3

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  55

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  56
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  brominated at position 3

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  56

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  57
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  iodinated at position 3

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  57

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  58
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  iodinated at positions 3 and 5

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  58

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  59
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  amidated at position 4

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  59

Phe Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  60
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = homotyrosine (hTyr)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  60

Xaa Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  61
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 4-Cl-phenylalanine (Cpa)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  61

Xaa Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  62
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with aminomethyl group at postion 4

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  62

Phe Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  63
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  fluorinated at positions 3, 4 and 5

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  63

Phe Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  64
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  fluorinated at position 3

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  64

Phe Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  65
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  fluorinated at positions 3 and 4

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  65

Phe Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  66
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  fluorinated at positions 3 and 5

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  66

Phe Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  67
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  hydroxylated at position 3

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  67

Phe Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  68
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  hydroxylated at position 3

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  68

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  69
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  O-methyl at position 3

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  69

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  70
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  70

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  71
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  methylated at positions 2 and 6

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  71

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  72
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  methylation

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  72

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  73
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  fluorinated at position 4

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  73

Phe Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  74
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = beta-(4-pyridinyl)alanine (4Pal)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  74

Xaa Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  75
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = beta-(3-pyridinyl)alanine (3Pal)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  75

Xaa Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  76
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa =  beta-(4-thiazolyl)alanine (Taz)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  76

Xaa Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  77
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with NO2 group at position 3

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  77

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  78
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa =  beta-(3-thienyl)alanine (3Thi)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  78

Xaa Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  79
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with CN at position 4

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  79

Phe Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  80
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  fluorinated at position 3

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  80

Tyr Gly Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Xaa Thr Gln 
        35                  40          


<210>  81
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(2)
<223>  pseudopeptide bond

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  81

Tyr Gly Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  82
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  fluorinated at position 3

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  82

Phe Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  83
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  chlorinated at position 3

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  83

Phe Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  84
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  brominated at position 3

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  84

Phe Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  85
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  chlorinated at position 3

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  85

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  86
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  brominated at position 3

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  86

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  87
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = beta-tyrosine (-Tyr)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  87

Xaa Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  88
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  fluorinated at position 3

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  88

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  89
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  fluorinated at position 2

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  89

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  90
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = a-methyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  90

Xaa Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  91
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  AMIDATION at position 3

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  91

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  92
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = beta-(2-pyridinyl)alanine (2Pal)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  92

Xaa Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  93
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (HO-CH2) at position 3

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  93

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  94
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  methylated at positions 2 and 6

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  94

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  95
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  methylated at positions 2 and 6

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  95

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  96
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  methylated at positions 2 and 6

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  96

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  97
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  97

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Gly Lys Lys Asn Asp Trp Lys His 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


<210>  98
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  modified with N-propylsuccinimide (Psu)

<400>  98

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Gly Lys Lys Asn Asp Trp Lys His 
            20                  25                  30          


Asn Cys Thr Gln 
        35      


<210>  99
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (33)..(33)
<223>  modified with N-propylsuccinimide (Psu)

<400>  99

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Gly Lys Lys Asn Asp Trp Lys His 
            20                  25                  30          


Cys Ile Thr Gln 
        35      


<210>  100
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  modified with N-propylsuccinimide (Psu)

<400>  100

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Gly Lys Lys Asn Asp Trp Lys Cys 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


<210>  101
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  modified with N-propylsuccinimide (Psu)

<400>  101

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Gly Lys Lys Asn Asp Cys Lys His 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


<210>  102
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  modified with N-propylsuccinimide (Psu)

<400>  102

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Gly Lys Lys Asn Cys Trp Lys His 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


<210>  103
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  modified with N-propylsuccinimide (Psu)

<400>  103

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Gly Lys Lys Cys Asp Trp Lys His 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


<210>  104
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  modified with N-propylsuccinimide (Psu)

<400>  104

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Gly Lys Cys Asn Asp Trp Lys His 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


<210>  105
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  modified with N-propylsuccinimide (Psu)

<400>  105

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Gly Cys Lys Asn Asp Trp Lys His 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


<210>  106
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  modified with N-propylsuccinimide (Psu)

<400>  106

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Cys Lys Lys Asn Asp Trp Lys His 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


<210>  107
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  modified with N-propylsuccinimide (Psu)

<400>  107

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Gly Lys Lys Asn Asp Trp Cys His 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


<210>  108
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa = ornithine (Orn)

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  modified with (N-C(O)-(CH2)12-CH3)

<400>  108

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Xaa Lys Lys Asn Asp Trp Lys His 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


<210>  109
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa = ornithine (Orn)

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  modified with (N-C(O)-(CH2)8-CH3)

<400>  109

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Xaa Lys Lys Asn Asp Trp Lys His 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


<210>  110
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa = ornithine (Orn)

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  modified with (N-C(O)-(CH2)8-CH3)

<400>  110

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Xaa Lys Lys Asn Asp Trp Lys His 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


<210>  111
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with CH3-(CH2)8-C(O)

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa = ornithine (Orn)

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  modified with (N-C(O)-(CH2)8-CH3)

<400>  111

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Xaa Lys Lys Asn Asp Trp Lys His 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


<210>  112
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa = ornithine (Orn)

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  modified with (N-C(O)-(CH2)4-CH3)

<400>  112

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Xaa Lys Lys Asn Asp Trp Lys His 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


<210>  113
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa = ornithine (Orn)

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  modified with (N-C(O)-(CH2)4-CH3)

<400>  113

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Xaa Lys Lys Asn Asp Trp Lys His 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


<210>  114
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with CH3-(CH2)4-C(O)

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa = ornithine (Orn)

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  modified with (N-C(O)-(CH2)4-CH3)

<400>  114

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Xaa Lys Lys Asn Asp Trp Lys His 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


<210>  115
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa = ornithine (Orn)

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  modified with (N-C(O)-(CH2)8-CH3)

<400>  115

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Gly Lys Lys Xaa Asp Trp Lys His 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


<210>  116
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa = ornithine (Orn)

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  modified with (N-C(O)-(CH2)8-CH3)

<400>  116

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Gly Lys Lys Xaa Asp Trp Lys His 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


<210>  117
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with CH3-(CH2)8-C(O)

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa = ornithine (Orn)

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  modified with (N-C(O)-(CH2)8-CH3)

<400>  117

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Gly Lys Lys Xaa Asp Trp Lys His 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


<210>  118
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  modified with N-hexylsuccinimide (Hsu)

<400>  118

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Cys Lys Lys Asn Asp Trp Lys His 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


<210>  119
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  modified with N-hexylsuccinimide (Hsu)

<400>  119

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Cys Lys Lys Asn Asp Trp Lys His 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


<210>  120
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa = beta-(2-naphthyl)alanine (2Nal)

<400>  120

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Xaa Lys Lys Asn Asp Trp Lys His 
            20                  25                  30          


Asn Ile Thr Gln 
        35      


<210>  121
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  121

Xaa Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His 
1               5                   10                  15      


Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys Lys Asn 
            20                  25                  30          


Asp Trp Lys His Asn Ile Thr Gln 
        35                  40  


<210>  122
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  122

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Gly Lys Lys Asn Asp Trp Lys His 
            20                  25                  30          


Asn Ile Thr Gln Gln 
        35          


<210>  123
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  modified with N-propylsuccinimide (Psu)

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  AMIDATION

<400>  123

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Cys Lys Lys Asn 
            20                  25              


<210>  124
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  modified with N-propylsuccinimide (Psu)

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  AMIDATION

<400>  124

Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe 
1               5                   10                  15      


Val Asn Trp Leu Leu Ala Gln Lys Cys 
            20                  25  


<210>  125
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  modified with N-propylsuccinimide (Psu)

<400>  125

Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp 
1               5                   10                  15      


Phe Val Asn Trp Leu Leu Ala Gln Lys Cys Lys Lys Asn Asp Trp Lys 
            20                  25                  30          


His Asn Ile Thr Gln 
        35          


<210>  126
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  modified with N-propylsuccinimide (Psu)

<400>  126

Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp 
1               5                   10                  15      


Phe Val Asn Trp Leu Leu Ala Gln Lys Cys Lys Lys Asn Asp Trp Lys 
            20                  25                  30          


His Asn Ile Thr Gln 
        35          


<210>  127
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  AMIDATION

<400>  127

Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp 
1               5                   10                  15      


Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25  


<210>  128
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  modified with N-propylsuccinimide (Psu)

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  AMIDATION

<400>  128

Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp 
1               5                   10                  15      


Phe Val Asn Trp Leu Leu Ala Gln Lys Cys 
            20                  25      


<210>  129
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  modified with N-propylsuccinimide (Psu)

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  AMIDATION

<400>  129

Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp 
1               5                   10                  15      


Phe Val Asn Trp Leu Leu Ala Gln Lys Cys 
            20                  25      


<210>  130
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  AMIDATION

<400>  130

Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys Ile His Gln Gln Asp 
1               5                   10                  15      


Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25  


<210>  131
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  AMIDATION

<400>  131

Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys Ile His Gln Gln Asp 
1               5                   10                  15      


Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25  


<210>  132
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  AMIDATION

<400>  132

Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys Ile His Gln Gln Asp 
1               5                   10                  15      


Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25  


<210>  133
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  modified with N-propylsuccinimide (Psu)

<400>  133

Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe Val Asn 
1               5                   10                  15      


Trp Leu Leu Ala Gln Lys Gly Lys Cys Asn Asp Trp Lys His Asn Ile 
            20                  25                  30          


Thr Gln 
        


<210>  134
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa = ornithine (Orn)

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  modified with (N-C(O)-(CH2)8-CH3)

<400>  134

Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe Val 
1               5                   10                  15      


Asn Trp Leu Leu Ala Gln Lys Xaa Lys Lys Asn Asp Trp Lys His Asn 
            20                  25                  30          


Ile Thr Gln 
        35  


<210>  135
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with cyclohexyl carboxylic acid (Chc)

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  modified with N-propylsuccinimide (Psu)

<400>  135

Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe Val 
1               5                   10                  15      


Asn Trp Leu Leu Ala Gln Lys Cys Lys Lys Asn Asp Trp Lys His Asn 
            20                  25                  30          


Ile Thr Gln 
        35  


<210>  136
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with CH3-(CH2)4-C(O)

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  modified with N-propylsuccinimide (Psu)

<400>  136

Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile His Gln Gln Asp Phe Val 
1               5                   10                  15      


Asn Trp Leu Leu Ala Gln Lys Cys Lys Lys Asn Asp Trp Lys His Asn 
            20                  25                  30          


Ile Thr Gln 
        35  


<210>  137
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa =  3-(4-hydroxyphenyl)propionic acid (4Hppa)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  137

Xaa Xaa Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys Ile 
1               5                   10                  15      


His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys Lys 
            20                  25                  30          


Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40      


<210>  138
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa =  3-(4-hydroxyphenyl)propionic acid (4Hppa)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = norleucine (Nle)

<400>  138

Xaa Pro Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Xaa Asp Lys Ile 
1               5                   10                  15      


His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys Lys 
            20                  25                  30          


Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40      


<210>  139
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa =  3-(4-hydroxyphenyl)propionic acid (4Hppa)

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<400>  139

Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Met Asp Lys Ile 
1               5                   10                  15      


His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys Lys 
            20                  25                  30          


Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40      


<210>  140
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa =  3-(4-hydroxyphenyl)propionic acid (4Hppa)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  140

Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Xaa Asp Lys Ile 
1               5                   10                  15      


His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys Lys 
            20                  25                  30          


Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40      


<210>  141
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa =  3-(4-hydroxyphenyl)propionic acid (4Hppa)

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  141

Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys Ile 
1               5                   10                  15      


His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys Lys 
            20                  25                  30          


Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40      


<210>  142
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<400>  142

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  143
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<400>  143

Tyr Xaa Glu Gly Thr Phe Ile Ser Xaa Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  144
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<400>  144

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  145
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<400>  145

Tyr Xaa Glu Gly Xaa Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  146
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  146

Tyr Xaa Glu Gly Xaa Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  147
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  147

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  148
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  148

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Xaa Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  149
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<400>  149

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Xaa Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  150
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<400>  150

Tyr Xaa Glu Gly Thr Phe Ile Xaa Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  151
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<400>  151

Tyr Xaa Glu Xaa Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  152
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  152

Tyr Xaa Glu Gly Xaa Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  153
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  153

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  154
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  154

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Xaa Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  155
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  155

Tyr Xaa Glu Xaa Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  156
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  156

Tyr Xaa Glu Gly Xaa Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  157
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  157

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  158
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  158

Tyr Xaa Glu Gly Thr Phe Ile Xaa Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  159
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  159

Tyr Xaa Glu Gly Thr Phe Ile Ser Xaa Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  160
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  160

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  161
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  161

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Xaa Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  162
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  162

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Xaa Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  163
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<400>  163

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Xaa Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  164
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<400>  164

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  165
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<400>  165

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Xaa Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  166
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<400>  166

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  167
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  167

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Xaa Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  168
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  168

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Xaa Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  169
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  169

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Xaa Thr Gln 
        35                  40          


<210>  170
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  170

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  171
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<400>  171

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Xaa Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  172
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  172

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  173
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  173

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  174
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  174

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  175
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  175

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  176
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  176

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  177
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  177

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  178
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  178

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Xaa His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  179
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  179

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  180
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  180

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  181
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  181

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  182
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  182

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  183
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  183

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  184
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  184

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  185
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  185

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  186
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  186

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  187
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  187

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  188
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  188

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  189
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  189

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  190
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  190

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  191
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  191

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  192
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  192

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  193
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  193

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  194
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  194

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  195
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  195

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  196
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  196

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  197
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  197

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  198
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  198

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  199
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  199

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  200
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  200

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  201
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<400>  201

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  202
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  202

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  203
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  203

Tyr Ala Pro Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  204
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa = homoproline (hPro)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  204

Tyr Ala Xaa Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  205
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa = 3,4-dehydroproline (Dhp)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  205

Tyr Ala Xaa Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  206
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa = homoproline (hPro)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<400>  206

Tyr Ala Xaa Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  207
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa =  tetrahydroisoquinoline-3-carboxylic acid (Tic)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<400>  207

Tyr Ala Xaa Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  208
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<400>  208

Tyr Ala Xaa Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  209
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  209

Tyr Ala Xaa Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  210
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa =  tetrahydroisoquinoline-3-carboxylic acid (Tic)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  210

Tyr Ala Xaa Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  211
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa = 3-hydroxyproline (3Hyp)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  211

Tyr Ala Xaa Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  212
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa =  tetrahydroisoquinoline-3-carboxylic acid (Tic)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  212

Tyr Ala Xaa Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  213
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa =  homoproline (hPro)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  213

Tyr Ala Xaa Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  214
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (41)..(41)
<223>  modified with N-propylsuccinimide (Psu)

<400>  214

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Cys Gln 
        35                  40          


<210>  215
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa =  homoproline (hPro)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  215

Tyr Ala Xaa Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  216
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<400>  216

Tyr Ala Pro Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  217
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  217

Tyr Ala Pro Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  218
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  218

Tyr Ala Pro Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  219
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  modified with N-propylsuccinimide (Psu)

<400>  219

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Cys Thr Gln 
        35                  40          


<210>  220
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  modified with N-propylsuccinimide (Psu)

<400>  220

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Cys Ile Thr Gln 
        35                  40          


<210>  221
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  modified with N-propylsuccinimide (Psu)

<400>  221

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys Cys Asn Ile Thr Gln 
        35                  40          


<210>  222
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  modified with N-propylsuccinimide (Psu)

<400>  222

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Cys Lys His Asn Ile Thr Gln 
        35                  40          


<210>  223
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa =  tetrahydroisoquinoline-3-carboxylic acid (Tic)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  223

Tyr Ala Xaa Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  224
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa =  homoproline (hPro)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  224

Tyr Ala Xaa Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  225
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  225

Tyr Ala Xaa Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  226
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (35)..(35)
<223>  modified with N-propylsuccinimide (Psu)

<400>  226

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Cys Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  227
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  modified with N-propylsuccinimide (Psu)

<400>  227

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Cys Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  228
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  228

Tyr Ala Xaa Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  229
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa = 4-hydroxyproline (4Hyp)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  229

Tyr Ala Xaa Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  230
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa =  tetrahydroisoquinoline-3-carboxylic acid (Tic)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  230

Tyr Ala Xaa Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  231
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  modified with N-propylsuccinimide (Psu)

<400>  231

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Cys Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  232
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  232

Tyr Ala Pro Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  233
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  233

Tyr Ala Pro Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  234
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  234

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln Gln 
        35                  40              


<210>  235
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  modified with N-propylsuccinimide (Psu)

<400>  235

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Cys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  236
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (43)..(43)
<223>  modified with N-propylsuccinimide (Psu)

<400>  236

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln Cys 
        35                  40              


<210>  237
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  237

Tyr Ala Pro Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  238
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  238

Tyr Ala Pro Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  239
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  239

Tyr Ala Pro Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  240
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (33)..(33)
<223>  modified with N-propylsuccinimide (Psu)

<400>  240

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Cys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  241
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (37)..(37)
<223>  modified with N-propylsuccinimide (Psu)

<400>  241

Tyr Xaa Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Cys His Asn Ile Thr Gln 
        35                  40          


<210>  242
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa =  3-(4-hydroxyphenyl)propionic acid (4Hppa)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<400>  242

Xaa Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  243
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  243

Tyr Ala Pro Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  244
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = ornithine (Orn)

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with (N-C(O)-(CH2)12-CH3)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  244

Xaa Ala Glu Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  245
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  245

Tyr Xaa Pro Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  246
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  246

Tyr Xaa Pro Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  247
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  247

Tyr Xaa Pro Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  248
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  248

Tyr Xaa Pro Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  249
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  249

Tyr Xaa Pro Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  250
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = N-methyl-tyrosine (NMe-Tyr)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  250

Xaa Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  251
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclohexanecarboxylic acid (A6c)

<400>  251

Tyr Gly Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  252
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  252

Tyr Gly Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Xaa Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Xaa Thr Gln 
        35                  40          


<210>  253
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  253

Tyr Gly Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  254
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  254

Tyr Gly Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  255
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  fluorinated at position 3

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  255

Phe Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  256
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  fluorinated at position 3

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  256

Phe Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln His 
        35                  40              


<210>  257
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  fluorinated at position 3

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  257

Phe Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln His 
        35                  40              


<210>  258
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  fluorinated at position 3

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  258

Phe Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln His 
        35                  40              


<210>  259
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  259

Tyr Gly Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  260
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  260

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  261
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  261

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  262
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  AMIDATION

<400>  262

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys His 
            20                  25                  30      


<210>  263
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  263

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys 
            20                  25                  30  


<210>  264
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (42)..(42)
<223>  AMIDATION

<400>  264

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Cys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  265
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (42)..(42)
<223>  AMIDATION

<400>  265

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Cys Asn Asp Trp Lys His Asn Ile Xaa Gln 
        35                  40          


<210>  266
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (43)..(43)
<223>  AMIDATION

<400>  266

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln Cys 
        35                  40              


<210>  267
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa = ornithine (Orn)

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  modified with (N-C(O)-(CH2)10-CH3)

<400>  267

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Xaa 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  268
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa = ornithine (Orn)

<220>
<221>  MOD_RES
<222>  (33)..(33)
<223>  modified with (N-C(O)-(CH2)10-CH3)

<400>  268

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Xaa Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  269
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (43)..(43)
<223>  modified with (N-C(O)-(CH2)10-CH3)

<400>  269

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln Lys 
        35                  40              


<210>  270
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  modified with succinimide-N-(CH2)11-CH3

<400>  270

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Cys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  271
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (33)..(33)
<223>  modified with succinimide-N-(CH2)11-CH3

<400>  271

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Cys Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  272
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (43)..(43)
<223>  modified with succinimide-N-(CH2)11-CH3

<400>  272

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln Cys 
        35                  40              


<210>  273
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (43)..(43)
<223>  modified with (N-C(O)-(CH2)14-CH3)

<400>  273

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln Lys 
        35                  40              


<210>  274
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa = ornithine (Orn)

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  modified with (N-C(O)-(CH2)14-CH3)

<400>  274

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Xaa 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  275
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa = ornithine (Orn)

<220>
<221>  MOD_RES
<222>  (33)..(33)
<223>  modified with (N-C(O)-(CH2)14-CH3)

<400>  275

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Xaa Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  276
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  chlorinated at position 3

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  276

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  277
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  chlorinated at position 3

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  277

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  278
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  chlorinated at position 3

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  Xaa = ornithine (Orn)

<220>
<221>  MOD_RES
<222>  (43)..(43)
<223>  modified with (N-C(O)-(CH2)10-CH3)

<400>  278

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln Xaa 
        35                  40              


<210>  279
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  chlorinated at position 3

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MOD_RES
<222>  (43)..(43)
<223>  modified with succinimide-N-(CH2)11-CH3

<400>  279

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln Cys 
        35                  40              


<210>  280
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  brominated at position 3

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  280

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  281
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  brominated at position 3

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  281

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  282
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 3-O-methyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  282

Xaa Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  283
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 3-O-methyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  283

Xaa Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  284
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 3-O-methyl-tyrosine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  284

Xaa Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Xaa Gln His 
        35                  40              


<210>  285
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 4-trifluoromethyl-phenylalanine (4CF3-Phe)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  285

Xaa Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  286
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = 7-Hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid 
       (7HO-Tic)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  286

Xaa Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  287
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  methylated at position 4

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  287

Phe Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  288
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  modified with a cyano group (CN) at position 4

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  288

Phe Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  289
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = homotyrosine (hTyr)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<400>  289

Xaa Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln His 
        35                  40              


<210>  290
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  chlorinated at position 3

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MOD_RES
<222>  (43)..(43)
<223>  modified with (N-C(O)-(CH2)10-CH3)

<400>  290

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln Lys 
        35                  40              


<210>  291
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  chlorinated at position 3

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MOD_RES
<222>  (43)..(43)
<223>  modified with (N-C(O)-(CH2)10-CH3)

<400>  291

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln Lys 
        35                  40              


<210>  292
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MOD_RES
<222>  (42)..(42)
<223>  AMIDATION

<400>  292

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  293
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  chlorinated at position 3

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa = norleucine (Nle)

<400>  293

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln Cys 
        35                  40              


<210>  294
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa = alpha-aminoisobutyric acid (Aib)

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid (A5c)

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa = norleucine (Nle)

<220>
<221>  MOD_RES
<222>  (42)..(42)
<223>  modified with (N-C(O)-(CH2)10-CH3)

<400>  294

Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Xaa Ile Ala Xaa Asp Lys Ile 
1               5                   10                  15      


His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys Lys 
            20                  25                  30          


Asn Asp Trp Lys His Asn Ile Thr Gln Lys 
        35                  40          


<210>  295
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic analog of glucose-dependent insulinotropic polypeptide 
       (GIP)


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa = 1-amino-1-cyclopentanecarboxylic acid

<400>  295

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


